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KMID : 0360919640070090855
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Journal of the Korean Medical Association
1964 Volume.7 No. 9 p.855 ~ p.871
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THE STUDIES OF THERAPEUTIC EFFECTS OF HEXACHLOROPHENE, HEXACHLOROPHENE N-ETHYL PYRIDINATE AND HEXACHLOROPHENE PIPERAZINATE ON LIVER FLUKE, CLONORCHIASIS SINESIS
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金鍾石/Kim, Chong Suk
金重瑛/金和雄/朴永春/Kim, Chung Young/Kim, Hwa Woong/Park, Young Choon
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Abstract
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The potential parasiticidal effects of hexachlorophene on liver fluke in vo, and in experimental animals had been found in our laboratory from September to December 1962.
We tried to use henachlorophene on liver fluke patients, but the side effects and toxicity of hexachlorophene were severe, so we could not use hexachlorphene on clinical application.
We derived 32 derivatives and quarternary ammonium salt from hexachlorophene and examined their parasiticidal effects and toxicity. We selected two sorts of ammonium salts, hexachlorophene N-ethylpyridinate and hexachlorophene piperazinate, andappliea them to clinical use.
In experimental animals, we found that hexachlomphene N-ethyl pyridinate, hexachlorophene piperazinate had lesser toxicity than hexachlorophene, but herapeutic effects were decreased In hexachloropheneN-ethyl Pyridinate and increased in hexachlorophenepiperazinate.
We administered hexachlorophone, hexachlgrophene N-ethyl pyridinate and hexachlorophene piperazinateorally to patients who called at our Department of Pharmacology, Kyung Pook National University for16 months from January 1963 to May 1964.
Method and dosage of each drugs are as follow:
Hexachlorophene:
250 mg./day for 5 days to l5 patients, 7 days to 36patients, 10 days to 9patieents.
300mg /day for 5 days to 13 patients, 7 days to 27patients, 10 days to 18patients, 13 days to22 patients.
400mg./day for 7 days to 8 patients, 10 days to 13patients, each otherday for 14 days to 25patients.
Hexachlorophene N-ethyl pyridinate:
400 mg./day for 14 days to 6 patients.
500 mg./dalr for 14 days to 32 patient3.
Hexachlorophene piperzinate:
300 mg./day for 21 days to 42 patients.
400 mg./day for 21 days to 66 patients.
Each drug was given orally two times a day immediately after meals. We observed the change of EPG in stool and clinical symptoms and side effects.
We found the results as follow:
1. Eggs change in stool ; EPG increased in patients´stool from 3rd day of treatment, and maximal count of EPG was found from 5th to 7th day of treatment and that was 3-5 times of the count before the administration of the drugs, and almost negative results could be found after 10-l5th day of treatment.
Negative results of hexachlorophene 250 mg..300 mg. for 5 days administrated group was 6669%, 250mg,, 300mg.. for 7 days administrated group was 74-75% . 250 mg. for 10 days, 300 mg.for 7 days and 400mg. every other day for 14days were 74-77% , and 300 mg. for 10-13 days,4OO mg. 7-10 days administrated group were 83-92% .
Negative results of hexachlomphene N-ethylpyridinate 400-5OO mg. for 14 days was 83-93% .Negative results of hexachlorophene piperazinate 300 mg.,
400 mg. for· 21 days was 90-92% .
2. During and after treatment of liver fluke with these drugs, we found that liver enlargement, jaundice and as cites were diminished gradually, liver function and general conditions were improved.
3. The side effects of these drugs were headache, dizziness, ocular pain, dysuria, visual disturbances, fatigue, anorexia, nausea, abdominal pain diarrhea,and perspiration, and the chief side effects were headache, ocular pain, and dysuria. The rate ofside effects of hexachlorophene were 41.6-57.1%in all cases, hexachloropone N-ethyl pyridinate was 46.8% in 500 mg. case, and hexachloro phenepiperazinate were 23.8-27.2% in all cases. Hexachlorfphene piperazinate has lesser toxicity and would be a better drug than the other two drugs.
4. We think that hexachlorophene has remarkable therapeutic effect on liver fluke patients, but it is not safe to use it clinically due to its toxicity .Hexachlorophene N-ethyl pyridinate would be useful on liver flute patients if we use it carefully. Hexachlorophene piperafinate would be a therapeutic drug on liver fluke patients if we take care of its side effects of headache, ocular pain, and dysuria.
5. It is very important to discontinue the administration of these drugs immediately when the chief side effects appeared.
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